研究業績

研究論文

<2017>

Fukuda A, Usui M, Wakao H, Boonla C, Tamura Y . Stenotrophomonas maltophilia is highly prevalent among houseflies (Musca domestica).
J. Med. Microbiol. in press


Harada K, Shimizu T, Mukai Y, Kuwajima K, Sato T, Kajino A, Usui M, Tamura Y, Kimura Y, Miyamoto T, Tsuyuki Y, Ohki A, Kataoka Y. Phenotypic and molecular characterization of antimicrobial resistance in Enterobacter spp. isolates from companion animals in Japan. PLOS ONE. 2017. 12: e0174178.


Yukawa S, Tsuyuki Y, Sato T, Fukuda A, Usui M, Tamura Y. Antimicrobial resistance of Pseudomonas aeruginosa isolated from dogs and cats in primary veterinary hospitals in Japan. Jpn. J. Infect. Dis. 2017. in press.


Ohishi T, Aoki K, Ishii Y, Usui M, Tamura Y, Kawanishi M, Onishi K, Tateda K.Molecular epidemiological analysis of human- and chicken-derived isolates of CampyloOhishi T, Aoki K, Ishii Y, Usui M, Tamura Y, Kawanishi M, Onishi K, Tateda K.Molecular epidemiological analysis of human- and chicken-derived isolates of Campylobacter jejuni in Japan using next-generation sequencing. J. Infect. Chemother. 2017. 23.165-172.


Usui M, Kawakura M, Yoshizawa N, San LL, Nakajima C, Suzuki Y, Tamura Y. Survival and prevalence of Clostridium difficile in manure compost derived from pigs. Anaerobe. 2017. 43. 15-20.


Sato T, Suzuki Y, Shiraishi T, Honda H, Shinagawa M, Yamamoto S, Ogasawara N, Takahashi H, Takahashi S, tamura Y, Yokoat S. Tigecycline non-susceptibility occurs exclusively in fluoroquinolone-resistant Escherichia coli clinical isolates, including the major multidrug-resistant lineages O25b:H4-ST131-H30R and O1-ST648. Antimicrob. Agents Chemother. 2017. 61. e01654-16.

<2016>

Sato T, Fukuda A, Suzuki Y, Shiraishi T, Honda H, Shinagawa M, Yamamoto S, Ogasawara N, Usui M, Takahashi H, Takahashi S, Tamura Y, Yokota S. Pathogenic Lineage of mcr-Negative Colistin-Resistant Escherichia coli, Japan, 2008-2015 . Emerg. Infec. Dis. 2016. 12. 2223-2225.


Harada K, Shimizu T, Mukai Y, Kuwajima K, Sato T, Usui M, Tamura Y, Kimura Y, Miyamoto T, Tsuyuki Y, Ohki A, Kataoka Y. Phenotypic and molecular characterization of antimicrobial resistance in Klebsiella spp. isolates from companion animals in Japan: clonal dissemination of multidrug-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae. Front. Microbiol. 2016. 7. 021.


Usui M, Tagaki C, Fukuda A, Okubo T, Boonla C, Suzuki S, Seki K, Takada H, Tamura Y. Use of Aeromonas spp. as general indicators of antimicrobial susceptibility among bacteria in aquatic environments in Thailand. Front. Microbiol. 2016. 7. 710. 


Furusawa T, Iwano H, Higuchi H, Usui M, Maruyama F, Nakagawa I, Yokota H,  Tamura Y. Complete Genome Sequencing of the Broad-Host-Range Pseudomonas aeruginosa Bacteriophages ΦR18 and ΦS12-1. Genome Announcement. 2016. 5. e00041-16.


Furusawa T, Iwano H, Higuchi H, Yokota H, Usui M, Tamura Y. Bacteriophage can lyse antibiotic-resistant Pseudomonas aeruginosa isolated from canine diseases. J Vet Med Sci. 2016. 78. 1035-1038


Changkwanyeun R, Yamaguchi T, Kongsoi S, Changkaew K, Yokoyama K, Kim H, Suthienkul O, Usui M, Tamura Y, Nakajima C, Suzuki Y.Impact of mutations in DNA gyrase genes on quinolone resistance in Campylobacter jejuni. Drug Testing and Analysis. 2016. in press.


Fukuda A, Usui M, Okubo T, Tamura Y. Horizontal transfer of plasmid-mediated cephalosporin-resistance genes in the intestine of houseflies (Musca domestica). Microb Drug Res. 2016. 22. 336-341.


Usui M, Suzuki K,  Oka K, Miyamoto K, Takahashi M, Inamatsu T, Kamiya S, Tamura Y. Distribution and characterization of  Clostridium difficile isolated from dogs in Japan. Anaerobe. 2016. 37. 58-61.

<2015>

Lan Thanh Bien T, Sato-Takabe Y, Ogo M, Usui M, Suzuki S. Persistence of multi-drug resistance plasmids in sterile water under very low concentration of tetracycline. Microbes and Environments. 2015. 30. 339-343.


Ishihara K, Koizumi A, Saito M, Muramatsu Y, Tamura Y. Detection of MRSP ST169 and novel ST354 SCCmec II-III isolates related to the worldwide ST71 clone. Epidemiol Infect. 2015. 1-9.


Yukawa S, Tamura Y, Tanaka K, Uchida I. Rapid detection of Salmonella enterica serovar Typhimurium DT104 strains by the PCR. Acta Vet Scand. 2015. 25. 59.


Makita K, Goto M, Ozawa M, Kawanishi M, Koike R, Asai T, Tamura Y. Multivariable analysis of the association between antimicrobial use and antimicrobial reistance in Escherichia coli isolated from apparently healthy pigs in Japan. Microb Drug Res. 2015. 22. 28-39.


Sato T, Usui M, Motoya T, Sugiyama T, Tamura Y.  Characterisation of methicillin-resistant Staphylococcus aureus ST97 and ST5 isolated from pigs in Japan. Journal of Global Antimicrobial Resistance. 2015. 3. 283-285.


Changkwanyeun R, Usui M, Kongsoi S, Yokoyama K, Kim H, Suthienkul O, Changkaew K, Nakajima C, Tamura Y, Suzuki Y. Characterization of Campylobacter jejuni DNA gyrase as the target of quinolones. J Infect Chemother. 2015. 21. 604-609.


Usui M, Shirakawa T, Fukuda A, Tamura Y.  The role of flies in disseminating plasmids with antimicrobial-resistance genes between farms. Microbial Drug Resistance. 2015. 21. 562-569.

<2014>

Okubo T, Tosaka Y, Sato T, Usui M, Nakajima C, Suzuki Y, Imura S, Tamura Y. Bacterial diversity in sea ice from Southern ocean and the Sea of Okhotsk. J Appl Environ Microbiol. 2014. 2. 266-272.


Makita K, Inoshita K, Kayano T, Uenoyama K, Hagiwara K, Asakawa M,Ogawa K, Kawamura S, Noda J, Sera K, Sasaki H, Nakatani N, Higuchi, H, Ishikawa N, Iwano H, Tamura Y. Temporal changes in environmental health risks associo-psychological status in areas affected by the 2011 tsunami in Ishinomaki, Japan. Environment and Pollution. 2014. 3: 1-20.


Tsukamoto N, Ohkoshi Y, Okubo T, Sato T, Kuwahara O, Fujii N, Tamura Y, Yokota S. High prevalence of cross-resistance to aminoglycosides in fluoroquinolone-resistant Escherichia coli clinical isolates. Chemotherapy. 2014. 59: 379-384


Uchida L, Heriyanto A, Thongchai C, Hanh Tran Thi, Horiuchi M, Ishihara K, Tamura Y, Muramatsu Y. Genetic diversity in the prion protein gene (PRNP) of domestic cattle and water buffaloes in Vietnam, Indonesia and Thailand. J Vet Med Sci. 2014. 76: 1001-1008.


Muramatsu Y, Usaki N, Thongchai C, Kramontong I, Kriegsak P, Tamura Y. Seroepidemiological survey in Thailand of Coxiella burnetii infection in cattle and chicken and presence in ticks attached to dairy cattle. SE Asian J Trop Med Publ Hlth. 2014. 45: 1167-1172.


Ishihara K, Saito E, Shimokubo N, Muramatsu M, Maetani S, Tamura Y. Epidemiological analysis of Mechicillin-resistant  Stapylo coccus aureus carriage among veterinary staffs for companion animals in Japan. 2014. J Vet Med Sci. 76: 1627-1629.


Ishihara K, Saito E, Shimokubo N, Muramatsu Y, Maetani S, Tamura Y. Mechicillin-resistant Stapylococcus aureus carriage among veterinary staffs and dogs in private veterinary clinics in Hokkaido, Japan .2014. Microbiol Immunol. 58: 149-154.


Usui M, Nanbu Y, Oka K, Takahashi M, Inamatsu T, Asai T, Kamiya S, Tamura Y. Genetic relatedness between Japanese and European isolates of Clostridium difficile originating from piglets and their risk associated with human health. Front. Microbiol. 2014. 5. 513.


Usui M, Uchida I, Tamura Y. Selection of macrolide-resistant Campylobacter in pigs treated with macrolides. Vet. Rec. 2014. 175. 430.


Hiki M, Usui M, Akiyama T, Kawanishi M, Tsuyuki M, Imamura S, Sekiguchi H, Kojima A, Asai T. Phylogenetic grouping, epidemiological typing, analysis of virulence genes, and antimicrobial susceptibility of Escherichia coli isolated from healthy broilers in Japan. Ir. Vet. J. 2014. 67:14.


Harada K, Usui M, Asai T.Application of enrofloxacin and orbifloxacin disks approved in Japan for susceptibility testing of representative veterinary respiratory pathogens. J. Vet. Med. Sci. 2014. in press.


Tsukamoto N, Ohkoshi Y, Okubo T, Sato T, Kuwahara O, Fujii N, Tamura Y, Yokota S. High prevalence of cross-resistance to aminoglycosides in fluoroquinolone-resistant Escherichia coli clinical isolates. Chemotherapy. 2014; 59, 379-384.


Sato T, Okubo T, Usui M, Yokota SI, Izumiyama S, Tamura Y. Association of veterinary third-generation cephalosporin use with the risk of emergence of extended-spectrum-cephalosporin resistance in Escherichia coli from dairy cattle in Japan. PLOS ONE. 2014; 9, e96101.


Sato T, Yokota SI, Ichihashi R, Miyauchi T, Okubo T, Usui M, Fujii N, Tamura Y.Isolation of Escherichia coli strains with AcrAB–TolC efflux pump-associated intermediate interpretation or resistance to fluoroquinolone, chloramphenicol, and aminopenicillin from dogs admitted to a university veterinary hospital. J. Vet. Med. Sci. 2014; 76, 937-945.


Usui M, Ozawa S, Onozato H, Kuge R, Obata Y, Uemae T, Ngoc PT, Heriyanto A, Chalemchaikit T, Makita K, Muramatsu Y, Tamura Y. Antimicrobial susceptibility of indicator bacteria isolated from chickens in Southeast Asian countries (Vietnam, Indonesia, and Thailand). J. Vet. Med. Sci.; 76, 685-692.


Usui M, Sakemi Y, Uchida I, Tamura Y. Effects of fluoroquinolone treatment and group housing of pigs on the selection and spread of fluoroquinolone-resistant Campylobacter. Vet. Microbiol.;170, 438-441.


Okubo T, Sato T, Yokota SI, Usui M, Tamura Y. Comparison of broad-spectrum cephalosporin-resistant Escherichia coli isolated from dogs and humans in Hokkaido, Japan. J Infect Chemother.; 20, 243-249.


Sato T, Yokota SI, Okubo T, Usui M, Fujii N, Tamura Y. Phylogenetic association of fluoroquinolone- and cephalosporin-resistance of D-O1-ST648 Escherichia coli carrying blaCMY-2 from fecal samples of dogs in Japan. J. Med. Microbiol.;63, 263-270.


Iwamoto T, Arikawa K, Nakajima C, Nakanishi N, Nishiuchi Y, Yoshida S, Tamaru A, Tamura Y, Hoshino Y, Yoo H, Park YK, Saito H, Suzuki Y. Intra-subspecies sequence variability of the MACPPE 12 gene in Mycobacterium avium subsp. hominissuis. Infect Genet Evol. 21, 479-483.

<2013>

Ishihara K, Nakajima K, Kishimoto S, Atarashi F, Muramatsu Y, Hotta A, Ishii S, Takeda Y, Kikuchi M, Tamura Y. Distribution of antimicrobial-resistant lactic acid bacteria in natural cheese in Japan. Microbiol. Immunol. 2013; 57, 684-691.


Izumiya H, Terajima J, Yamamoto S, Ohnishi M, Watanabe H, Kai A, Kurazono T, Taguchi M, Asai T, Akiba M, Matsumoto Y, Tamura Y. Genomic analysis of Salmonella enterica serovar Typhimurium definitive phage type 104. Emerg Infect Dis. 2013; 19, 823-825.


Sato T, Yokota S, Uchida I, Okubo T, Usui M, Kusumoto M, Akiba M, Fujii N, Tamura Y. Fluoroquinolone resistance mechanisms in an Escherichia coli isolate, HUE1, without quinolone resistance-determining region mutations. Front Microbiol. 2013. 4: 125.


Usui M, Iwasa T, Fukuda A, Sato T, Okubo T, Tamura Y. The Role of Flies in Spreading the Extended-Spectrum Beta-lactamase Gene from Cattle. Microbial Drug Resistance. 2013; 19, 415-420.


Sato T, Okubo T, Usui M, Higuchi H, Tamura Y. Amino acid substitutions in GyrA and ParC are associated with fluoroquinolone resistance in Mycoplasma bovis isolates from Japanese dairy calves. J. Vet. Med. Sci. 2013; 75, 1063-1065.


Usui M, Nagai H, Hiki M, Tamura Y, Asai T. Effect of antimicrobial exposure on AcrAB expression in Salmonella enterica subspecies enterica serovar Choleraesuis. Front. Microbiol., 2013.: 4. 53.


Usui M, Nagai H, Tamura Y.  An in vitro method for evaluating endotoxic activity using prostaglandin E2 induction in bovine peripheral blood. Biologicals, 2013; 41, 158-161.


Hiki M, Usui M, Kojima A, Ozawa M, Ishii Y, Asai T. Diversity of plasmid replicons encoding the blaCMY-2 gene in broad-spectrum cephalosporin-resistant Escherichia coli from livestock animals in Japan. Foodborne Pathog. Dis. 10(3):243-249.


Sato T, Yokota SI, Okubo T, Ishihara K, Ueno H, Muramatsu Y, Fujii N, Tamura Y. Contribution of the AcrAB-TolC Efflux Pump to High-Level Fluoroquinolone Resistance in Escherichia coli Isolated from Dogs and Humans. J Vet Med Sci. 2013; 75, 1063-1065.


Asai T, Usui M, Hiki M, Kawanishi M, Nagai H, Sasaki Y. Clostridium difficile Isolated from the Fecal Contents of Swine in Japan. J Vet Med Sci. 2013; 75, 539-541.

<2012>
Asai T, Hiki M, Baba K, Usui M, Ishihara K, Tamura Y. Presence of Staphylococcus aureus ST398 and ST9 in Swine in Japan. Jpn J Infect Dis. 2012;65(6):551-2.


Kurosawa A, Imamura T, Tanaka K, Tamamura Y, Uchida I, Kobayashi A, Hata E, Kanno T, Akiba M, Yukawa S, Tamura Y. Molecular typing of Salmonella enterica serotype Typhimurium and serotype 4,5,12:i:- isolates from cattle by multiple-locus variable-number tandem-repeats analysis. Vet Microbiol. 2012 Nov 9;160(1-2):264-8.


Ozawa M, Makita K, Tamura Y, Asai T. Association of antimicrobial use with antimicrobial resistance in Campylobacter coli from grow-finish pigs in Japan. Preventive Veterinary Medicine. 2012.:106:295-300.


Yokota S, Sato T, Okubo T, Ohkoshi Y, Okabayashi T, Kuwahara O, Tamura Y, Fujii N. Prevalence of fluoroquinolone-resistant Escherichia coli O25:H4-ST131 (CTX-M-15-nonproducing) strains isolated in Japan. Chemotherapy. 2012;58(1):52-9.


Baba K, Ishihara K, Ozawa M, Usui M, Hiki M, Tamura Y, Asai T. Prevalence and mechanism of antimicrobial resistance in Staphylococcus aureus isolates from diseased cattle, swine and chickens in Japan. J Vet Med Sci. 2012 May;74(5):561-5.


Iwamoto T, Nakajima C, Nishiuchi Y, Kato T, Yoshida S, Nakanishi N, Tamaru A, Tamura Y, Suzuki Y, Nasu M. Genetic diversity of Mycobacterium avium subsp. hominissuis strains isolated from humans, pigs, and human living environment. Infect Genet Evol. 2012 Jun;12(4):846-52.


Ishihara K, Hosokawa Y, Makita K, Noda J, Ueno H, Muramatsu Y, Ueno H, Mukai T, Yamamoto H, Ito M, Tamura Y. Factors associated with antimicrobial-resistant Escherichia coli in zoo animals. Res Vet Sci. 2012 Oct;93(2):574-80.


Ishihara K, Takahashi R, Andoh M, Ueno H, Muramatsu Y, Tamura Y. Seasonal variation in Campylobacter-contaminated retail chicken products: a year-round investigation in Japan. J Vet Med Sci. 2012 Jan;74(1):117-20.


Usui M, Hiki M, Murakami K, Ozawa M, Nagai H, Asai T. Evaluation of transferability of R-plasmid in bacteriocin-producing donors to bacteriocin-resistant recipients. Jpn J Infect Dis. 2012;65(3):252-5.


Sasaki Y, Usui M, Murakami M, Haruna M, Kojima A, Asai T, Yamada Y. Antimicrobial resistance in Shiga toxin-producing Escherichia coli O157 and O26 isolates from beef cattle. Jpn J Infect Dis. 2012;65(2):117-21.


<2011>
Ishihara K, Takahashi R, Andoh M, Makita K, Kamiji S, Ueno H, Muramatsu Y, Tamura Y. Effects of climatic elements on Campylobacter-contaminated chicken products in Japan. Epidemiol Infect. 2012 Jun;140(6):991-6.


Sato T, Yokota S, Uchida I, Okubo T, Ishihara K, Fujii N, Tamura Y. A fluoroquinolone-resistant Escherichia coli clinical isolate without quinolone resistance-determining region mutations found in Japan. Antimicrob Agents Chemother. 2011 Aug;55(8):3964-5.


Higuchi H, Iwano H, Kawai K, Ohta T, Obayashi T, Hirose K, Ito N, Yokota H, Tamura Y, Nagahata H. A simplified PCR assay for fast and easy mycoplasma mastitis screening in dairy cattle. J Vet Sci. 2011 Jun;12(2):191-3.


Harada K, Muramatsu M, Suzuki S, Tamura Y, Sawada T, Takahashi T. Evaluation on the pathogenicity of Erysipelothrix tonsillarum for pigs by immunosuppression with cyclophosphamide or dexamethasone. Res Vet Sci. 2011 Feb;90(1):20-2.


Ishihara K, Kanamori K, Asai T, Kojima A, Takahashi T, Ueno H, Muramatsu Y, Tamura Y. Antimicrobial susceptibility of Escherichia coli isolates from wild mice in a forest of a natural park in Hokkaido, Japan. J Vet Med Sci. 2011 Sep;73(9):1191-3.


Sakemi Y, Tamura Y, Hagiwara K. Interleukin-6 in quarter milk as a further prediction marker for bovine subclinical mastitis. J Dairy Res. 2011 Feb;78(1):118-21.


Asai T, Masani K, Sato C, Hiki M, Usui M, Baba K, Ozawa M, Harada K, Aoki H, Sawada T. Phylogenetic groups and cephalosporin resistance genes of Escherichia coli from diseased food-producing animals in Japan. Acta Vet Scand. 2011 Oct 12;53:52.


Usui M, Asai T, Sato S. Low expression of AcrB in the deoxycholate-sensitive strains of Salmonella enterica subspecies enterica serovar Pullorum. Microbiol Immunol. 2011 May;55(5):366-8.

<2010>
Baba K, Ishihara K, Ozawa M, Tamura Y, Asai T. Isolation of meticillin-resistant Staphylococcus aureus (MRSA) from swine in Japan. Int J Antimicrob Agents. 2010 Oct;36(4):352-4.


Ishihara K, Shimokubo N, Sakagami A, Ueno H, Muramatsu Y, Kadosawa T, Yanagisawa C, Hanaki H, Nakajima C, Suzuki Y, Tamura Y. Occurrence and molecular characteristics of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius in an academic veterinary hospital. Appl Environ Microbiol. 2010 Aug;76(15):5165-74.


Kojima A, Morioka A, Kijima M, Ishihara K, Asai T, Fujisawa T, Tamura Y, Takahashi T. Classification and antimicrobial susceptibilities of enterococcus species isolated from apparently healthy food-producing animals in Japan. Zoonoses Public Health. 2010 Mar;57(2):137-41.


Asai T, Sato C, Masani K, Usui M, Ozawa M, Ogino T, Aoki H, Sawada T, Izumiya H, Watanabe H. Epidemiology of plasmid-mediated quinolone resistance in salmonella enterica serovar typhimurium isolates from food-producing animals in Japan. Gut Pathog. 2010 Dec 7;2(1):17.


Usui M, Uchiyama M, Baba K, Nagai H, Yamamoto Y, Asai T. Contribution of enhanced efflux to reduced susceptibility of Salmonella enterica serovar Choleraesuis to fluoroquinolone and other antimicrobials. J Vet Med Sci. 2011 Feb;73(2):279-82.


Deshapriya RM, Yuhashi S, Usui M, Kageyama T, Yamamoto Y. Identification of essential residues of CTLA-2alpha for inhibitory potency. J Biochem. 2010 Mar;147(3):393-404.


総説・著書
臼井優、田村豊:乳房炎治療ガイドライン、緑書房(2015)

臼井優、田村豊:動物微生物検査学、近代出版(2014)

田村 豊:現行ワクチンの種類,動物用ワクチン・バイオ医薬品研究会編,24-26,文永堂出版,東京(2011)

田村 豊:細菌感染症に対する化学療法(抗菌化学療法),動物の感染症(第三版),明石博臣,大橋和彦,小沼 操,菊池直哉,後藤義孝,高井伸二,宝達 勉編,57-63,近代出版,東京(2011)

その他
田村 豊:動物用抗菌薬と薬剤耐性についての問題点,第46回緑膿菌感染症研究会講演記録 p.66-70,2012